cell 745 words KG: ent-gene-1a8734a0
Contents

Somatostatin Receptor Neurons

🔬 Protein Info
Gene Symbolent-gene-1a8734a0
SSTR1High expression in cortex, hippocampus, amygdala
SSTR2Predominant in cortex and pituitary
SSTR3Widely distributed in cortex and thalamus
SSTR4High in hippocampus and cortex
SSTR5Expressed in cortex, basal ganglia, and pituitary
Gain controlRegulate the gain of neural circuits during information processing
Temporal precisionControl timing of neuronal firing during oscillations
Hippocampal SST neuronsSupport memory consolidation and pattern separation
Cortical processingMediate attention and sensory integration
Working memoryContribute to working memory maintenance
Neurotransmitter modulationInhibits both glutamate and GABA release
Neuromodulator releaseCo-release of neuropeptide Y and cortistatin
Synaptic plasticityRegulate long-term potentiation and depression
CortexAll layers, particularly layer 2/3 and layer 5
HippocampusCA1-CA3 strata radiatum and lacunosum-moleculare
KG Connections8 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

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Related Hypotheses (8)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.95
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.88
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
...
Score: 0.68

Related Analyses (13)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

Knowledge Graph (8 edges)

h-var-adc924c2d4 targets ent-gene-1a8734a0
ent-gene-1a8734a0 targeted_by h-var-adc924c2d4
h-var-b0b78b7090 targets ent-gene-1a8734a0
ent-gene-1a8734a0 targeted_by h-var-b0b78b7090
ent-gene-1a8734a0 data_in benchmark_ot_ad_answer_key:SST
benchmark_ot_ad_answer_key:SST data_in ent-gene-1a8734a0
h-3481330a targets ent-gene-1a8734a0
ent-gene-1a8734a0 targeted_by h-3481330a

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