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Home / Wiki / Clinical: DIAN-TU-001 Trial (NCT01760005)

clinical 4,560 words KG: DIAN-TU-001 Trial (NCT01760005) 2026-03-24

kind:clinical-trial section:clinical-trials state:published

Contents

DIAN-TU-001 Trial (NCT01760005)

Knowledge Graph

Related Hypotheses (10)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68 TREM2-mediated microglial tau clearance enhancement
Score: 0.49 TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41 TREM2-Dependent Microglial Senescence Transition
Score: 0.69 Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52

APOE-TREM2 Interaction Modulation
Score: 0.48 Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.44 TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.43 Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.42 Trans-Synaptic Adhesion Molecule Modulation
Score: 0.34

Related Analyses (5)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived Synaptic pruning by microglia in early AD
neurodegeneration · archived Circuit-level neural dynamics in neurodegeneration
neuroscience · archived Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (8)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40 Creation and validation of 3xAD-ChAT-Cre mouse model
validation · proposed · Score: 0.90 Adoptive transfer of TCRAβ-Tregs in AD mouse model
validation · proposed · Score: 0.90 cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40 Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40

Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40 Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.40 TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.40

Knowledge Graph (1 edges)

DIAN-TU-001 Trial (NCT01760005) references TREM2

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