clinical 1,564 words KG: ent-gene-adb197b4 2026-03-28
kind:clinical-trialsection:clinical-trialsstate:publishedtopic:kcnq2-encephalopathytopic:gene-therapytopic:aav
Contents

KCNQ2 Encephalopathy — Gene Therapy Preclinical Programs

🔬 Protein Info
Gene Symbolent-gene-adb197b4
Chromosome20q13.33
Function1. Vector: Recombinant AAV (serotype to be determined — AAV9, AAV-PHP.eB, or engineered)
IndicationKCNQ2 encephalopathy (KCNQ2-E)
GeneKCNQ2 (Kv7.2 potassium channel)
ModalityAAV gene therapy
Development StagePreclinical / Research
Delivery RouteTo be determined (ICV, ICM, or IV with BBB-crossing capsid)
Target PopulationPediatric patients (infancy to childhood)
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (22)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
TDP-43 Cryptic Exon–Targeted ASOs to Restore Hippocampal Gam
Score: 0.58
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (16)

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Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-adb197b4 data_in benchmark_ot_ad_answer_key:KCNQ2
benchmark_ot_ad_answer_key:KCNQ2 data_in ent-gene-adb197b4