disease 1,687 words KG: ent-dise-c3c74328
section:diseaseskind:diseasetopic:alzheimerstopic:parkinsonstopic:alstopic:ftdtopic:huntingtons
Contents

Calcium Dysregulation Across Neurodegenerative Diseases

Disease Info
Voltage-gated calcium channels (VGCC)L-type (Cav1.2, Cav1.3), N-type (Cav2.2), P/Q-type (Cav2.1), T-type (Cav3.x)
Ligand-gated channelsNMDA receptors, AMPA receptors, nicotinic acetylcholine receptors
Store-operated calcium entry (SOCE)STIM1 sensor + Orai1 channel
Endoplasmic reticulum (ER)Major intracellular store, release via IP₃ receptors and ryanodine receptors
MitochondriaRapid uptake via mitochondrial calcium uniporter (MCU), buffering during calcium overload
Plasma membrane calcium ATPase (PMCA)Low-capacity, high-affinity extrusion
Sodium-calcium exchanger (NCX)High-capacity, low-affinity
Calbindin-D28kFast cytosolic buffer
ParvalbuminSlow calcium buffer
CalmodulinCalcium sensor protein
DatabasesOMIMOrphanetClinicalTrialsPubMed

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 1.00
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.97
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.96
Transcriptional Autophagy-Lysosome Coupling
Score: 0.95
CYP46A1 Overexpression Gene Therapy
Score: 0.94

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (5)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
TRIM21 E3 ubiquitin ligase screen for stress granule regulat
exploratory · proposed · Score: 0.90
Autophagy receptor identification for stress granule elimina
exploratory · proposed · Score: 0.90
Autophagy receptor knockout effects on stress granule accumu
exploratory · proposed · Score: 0.85
Single-cell RNA sequencing analysis of microglial heterogene
exploratory · proposed · Score: 0.70