Contents

Cerebral Small Vessel Disease

Disease Info

Post-infectious CSVD	Certain infections (varicella-zoster virus, HIV, syphilis, tuberculosis) can cause small vessel vasculopathy through direct vessel wall invasion or immune-mediated damage.
Moya disease	Progressive stenosis of intracranial arteries with compensatory small vessel proliferation.
Sickle cell disease	Chronic hemolytic anemia and vaso-occlusion cause progressive small vessel injury and white matter damage.
Susac syndrome	Autoimmune endotheliopathy affecting small vessels of the brain, retina, and inner ear.
Deep/infratentorial CMBs	Located in basal ganglia, thalamus, brainstem, or cerebellum; associated with hypertensive arteriopathy and increased risk of deep intracerebral hemorrhage.
Strictly lobar CMBs	Located in cortical-subcortical regions; suggest cerebral-amyloid-angiopathy (CAA) and are associated with lobar hemorrhage risk and alzheimers.
Mixed pattern	Both deep and lobar CMBs; may reflect combined hypertensive and amyloid pathology.
Cortical atrophy	Widespread cortical thinning, particularly in frontal and parietal regions, correlates with executive dysfunction and processing speed decline.
Databases	OMIM Orphanet ClinicalTrials PubMed

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