disease 1,622 words KG: ent-dise-720d2d46 2026-03-24
kind:diseasesection:diseasesstate:published
Contents

FTD Subtype Comparison Matrix — bvFTD vs svPPA vs nfPPA vs logopenic

Disease Info
AnomiaWord-finding difficulty, particularly for low-frequency items
Single-word Comprehension DeficitLoss of word meaning, especially for objects
Surface DyslexiaReading words with irregular pronunciation
Object AgnosiaInability to recognize objects despite intact vision
Preserved Speech FluencyFluent, grammatically correct speech with empty content
Preserved RepetitionNormal repetition ability
AgrammatismOmission of function words, simplified grammar, short phrases
Hesitant/Slow SpeechEffortful, halting speech production
Phonological ErrorsSound-level errors (substitutions, transpositions)
Motor Speech ImpairmentApraxia of speech
Preserved Word ComprehensionUnderstanding of single words relatively intact
Preserved Object KnowledgeObject recognition maintained
DatabasesOMIMOrphanetClinicalTrialsPubMed

Knowledge Graph

Related Hypotheses (6)

Glymphatic-Mediated Tau Clearance Dysfunction
Score: 0.55
Dual-Circuit Tau Vulnerability Cascade
Score: 0.50
Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio
Score: 0.49
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51
Complement C1q Subtype Switching
Score: 0.44

Related Analyses (12)

How do pathological stress granules in neurodegeneration esc
neurodegeneration · failed
RNA binding protein dysregulation across ALS FTD AD
neurodegeneration · failed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (18)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40
Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study
clinical · proposed · Score: 0.40
Frontal and Temporal Lobe Selective Vulnerability in FTD — M
validation · proposed · Score: 0.40