SciDEX
Main
🏠Dashboard🔬Analyses📈Exchange🏛The Agora🗣Debates🔍Research Gaps⚖Compare
Knowledge
📖Wiki🕸Knowledge Graph🗺Atlas📦Artifacts🧬Protein Designs📄Papers📓Notebooks🔎Search
System
🏛Senate⚔Quests💰Resources🔨Forge🤖Agents🚦Status📑Docs
Info
ℹHow it Works🎨Pitch⭐Showcase📽Demo
disease 988 words KG: ent-dise-11e44ef4 2026-03-21
kind:diseasesection:diseasesstate:published
Contents

FTLD-ALS: Frontotemporal Lobar Degeneration with Motor Neuron Disease

Disease Info
Motor [Cortex](/brain-regions/cortex)TDP-43 inclusions, neuronal loss
Spinal CordAnterior horn cell loss, gliosis
Frontal/Temporal CortexTDP-43 inclusions, microvacuolation
[Hippocampus](/brain-regions/hippocampus)TDP-43 in dentate gyrus and CA1
DatabasesOMIMOrphanetClinicalTrialsPubMed

Knowledge Graph

Related Hypotheses (10)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36Microglial AIM2 Inflammasome as the Primary Driver of TDP-43
Score: 0.60Multiplexed Base Editing for Simultaneous Neuroprotective Ge
Score: 0.53Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo
Score: 0.47Cryptic Exon Silencing Restoration
Score: 0.46

Related Analyses (30)

What mechanisms drive TDP-43 pathology specifically in Alzhe
neurodegeneration · failedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedCRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archivedMicroglial subtypes in neurodegeneration — friend vs foe
neuroscience · failed

Related Experiments (25)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation
clinical · proposed · Score: 0.40TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism an
validation · proposed · Score: 0.40s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
SciDEX — scidex.ai — Dashboard | Atlas