disease 790 words KG: ent-dise-c9d39f60 2026-03-24
kind:diseasesection:diseasesstate:published
Contents

Glaucoma

Disease Info
Primary Open-Angle Glaucoma (POAG)Most common form, characterized by open anterior chamber angle and progressive optic nerve damage
Primary Angle-Closure Glaucoma (PACG)Acute or chronic obstruction of aqueous humor outflow through the iridocorneal angle
Normal-Tension Glaucoma (NTG)Optic nerve damage with normal intraocular pressure
Exfoliative GlaucomaAssociated with pseudoexfoliation material
Pigmentary GlaucomaCaused by pigment dispersion from the iris
Traumatic GlaucomaFollowing ocular injury
Uveitic GlaucomaAssociated with intraocular inflammation
MYOC (Myocilin)Primary gene for juvenile-onset POAG, encodes myocilin protein
OPTN (Optineurin)Associated with NTG, also linked to ALS
TBK1Regulates OPTN function, shared with ALS/FTD
CYP1B1Primary congenital glaucoma gene
WDR36Associated with POAG susceptibility
DatabasesOMIMOrphanetClinicalTrialsPubMed

Knowledge Graph

Related Hypotheses (17)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S
Score: 0.55
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95
Score: 0.69
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (9)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (4)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
tACS Connectivity Trial in Early Alzheimer's
clinical · proposed · Score: 0.40
Microbiome-Gut Barrier Signatures in ALS — Experiment Design
clinical · proposed · Score: 0.40