Levodopa Responsiveness in Corticobasal Syndrome

Disease Info

CBS	Neuronal loss in globus pallidus internus (GPi), substantia nigra pars reticulata (SNr), motor cortex
PD	Predominant loss of dopaminergic neurons in substantia nigra pars compacta (SNc)
Positive response	≥30% improvement in UPDRS-III
Negative response	<30% improvement
Sensitivity for CBS	~70-80% of CBS patients show no response
Specificity	High specificity when marked asymmetry and cortical signs present
Differential diagnosis	Helps distinguish from progressive supranuclear palsy (PSP) where some responsiveness may occur
Databases	OMIM Orphanet ClinicalTrials PubMed

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