disease 2,220 words KG: ent-dise-7f5fed13 2026-03-26
kind:diseasesection:diseasesstate:published
Contents

Narcolepsy

Disease Info
Prevalence0.02-0.05% of the global population (200-500 per million)
Excessive daytime sleepinessOverwhelming urge to sleep during the day
CataplexySudden loss of muscle tone triggered by strong emotions
Sleep paralysisTemporary inability to move during sleep transitions
Hypnagogic/hypnopompic hallucinationsVivid dream-like experiences at sleep onset or offset
Disrupted nighttime sleepFragmented sleep architecture
Incidence0.5-1 per 100,000 person-years
Age of onsetBimodal distribution — peaks at 15 years and 35 years
GenderSlight male predominance (1.3-1.5:1)
HLA-DQB1*06:02Present in >95% of type 1 narcolepsy cases
Family history10-40x increased risk in first-degree relatives
EnvironmentInfections (particularly Streptococcus pyogenes), vaccines, stress
DatabasesOMIMOrphanetClinicalTrialsPubMed

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