| Prevalence | 5-10% of cases |
| Frequency | 2-4 Hz delta waves in bursts |
| Localization | Frontal regions, often bilateral but asymmetric |
| Clinical significance | Correlates with executive dysfunction and frontal lobe involvement |
| Differential | Excludes Creutzfeldt-Jakob disease which shows more periodic patterns |
| Significance | May indicate significant cortical irritation |
| Alpha reactivity | Reduced or absent in most CBS patients |
| Sleep EEG | Fragmented sleep architecture, reduced REM sleep percentage |
| Spindle activity | Reduced sleep spindle density compared to age-matched controls |
| K-complexes | Decreased in CBS compared to controls |
| N20 amplitude | Significantly increased in CBS (cortical hyperexcitability) |
| N20 latency | Often prolonged in affected hemisphere |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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