disease 3,290 words KG: ent-dise-bac7d871 2026-03-24
kind:diseasesection:diseasesstate:published
Contents

Posterior Cortical Atrophy

Disease Info
Visual acuity problemsDespite normal eye examinations, patients report difficulty reading, especially small print
Object recognition deficitsDifficulty identifying objects, faces (prosopagnosia), and places
Spatial disorientationProblems with navigation, judging distances, and finding items in familiar environments
Reading difficultyLetters seem to move or disappear, difficulty following lines of text
Color perception changesReduced ability to perceive and differentiate colors
Visuospatial neglectInattention to one side of visual space
Elemental visual disturbancesDifficulty with motion perception, depth perception, and form discrimination
SimultagnosiaInability to perceive more than one object at a time, leading to difficulty with complex visual scenes
Optic ataxiaDifficulty reaching for objects under visual guidance, with misreaching to targets
Gaze apraxiaDifficulty voluntarily directing gaze toward objects, requiring head movements to compensate
AgraphiaDifficulty writing, particularly with letter formation
AcalculiaDifficulty with arithmetic calculations, even with simple operations
DatabasesOMIMOrphanetClinicalTrialsPubMed

Knowledge Graph

Related Hypotheses (12)

Prime Editing Precision Correction of APOE4 to APOE3 in Micr
Score: 0.62
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68

Related Analyses (6)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (4)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40
Sex Differences in Alzheimer's Disease — mechanisms and ther
clinical · proposed · Score: 0.40