Contents

Prodromal Corticobasal Syndrome

Disease Info

Executive dysfunction	Difficulty with planning, multitasking, and problem-solving
Language difficulties	Subtle word-finding difficulties, reduced verbal fluency
Visuospatial deficits	Especially in right-hemisphere predominant cases
Memory complaints	Often mild, not typically amnestic pattern
Focal hand dystonia	Particularly in the dominant hand
Mild bradykinesia	Often asymmetric
Myoclonus	May appear as subtle jerks, often first noticed by family
Alien limb sensation	Some patients report early foreign limb sensations
MRI	Subtle asymmetric frontoparietal atrophy, particularly in precentral gyrus
FDG-PET	Hypometabolism in contralateral frontoparietal regions
Tau PET	Variable, may show focal uptake in motor cortex
Neurofilament light chain (NfL)	Elevated in CBS vs. controls
Databases	OMIM Orphanet ClinicalTrials PubMed

Knowledge Graph