| REM sleep behavior disorder (RBD) | one of the strongest prodromal markers[@schenck1996], [@iranzo2014] |
| [GBA](/entities/gba) gene mutations | Associated with earlier onset and more severe non-motor symptoms[@de2024] |
| [LRRK2](/entities/lrrk2) gene mutations | Common in familial PD |
| SNCA gene duplications | Associated with alpha-synuclein pathology |
| PARKIN mutations | Early-onset PD with prominent autonomic dysfunction |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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