disease 3,312 words KG: ent-dise-4d1cc4ef 2026-03-23
kind:diseasesection:diseasesstate:published
Contents

Progressive Supranuclear Palsy

Disease Info
Cognitive impairmentExecutive dysfunction, slowed processing speed
Speech difficultiesDysarthria, reduced speech volume
Swallowing problemsDysphagia, risk of aspiration
Sleep disturbancesREM sleep behavior disorder
Urinary dysfunctionUrgency, frequency
DatabasesOMIMOrphanetClinicalTrialsPubMed

Knowledge Graph

Related Hypotheses (19)

SASP-Mediated Cholinergic Synapse Disruption
Score: 0.56
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
Smartphone-Detected Motor Variability Correction
Score: 0.56
Ferroptosis Inhibition for α-Synuclein Neuroprotection
Score: 0.55
Phase-Separated Organelle Targeting
Score: 0.52

Related Analyses (11)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

Related Experiments (30)

s:** - Test tau spreading in AQP4 knockout vs wild-type mice
falsification · proposed · Score: 0.40
s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.40
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40