| Vertical supranuclear gaze palsy | Downgaze impairment typically appears first |
| Postural instability | Falls within first year of symptoms |
| Axial rigidity | Neck and trunk stiffness, progressive akinesia |
| Frontal cognitive dysfunction | Executive impairment, behavioral changes |
| Pseudobulbar affect | Emotional incontinence |
| Asymmetric onset | Unlike classic PSP |
| Resting tremor | Present in ~50% of cases |
| Levodopa response | Transient or modest benefit |
| Less prominent gaze palsy | May develop later |
| Later onset of falls | Typically after 2-3 years |
| Gait freezing | Difficulty initiating walking, episodic freezing |
| Micrographia | Small handwriting |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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