disease 1,089 words KG: ent-dise-520a56c3
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Cognitive Impairment in Progressive Supranuclear Palsy

Disease Info
Reduced verbal fluencyBoth phonemic and category fluency are impaired, with early deficits in letter-based word generation[@rascovsky2001]
Impaired set-shiftingDifficulties with the Wisconsin Card Sorting Test reflect disrupted task-switching abilities[@grafman1995]
Planning and organizationReduced performance on tasks requiring sequential planning, such as the Tower of London test[@phuong2019]
Working memory deficitsImpaired maintenance and manipulation of information in working memory[@dubois2000]
Reduced attention spanDifficulty maintaining sustained attention on tasks[@cotter2018]
Selective attentionImpaired ability to filter irrelevant stimuli
Divided attentionSignificant problems with multitasking
Retrieval deficitsDifficulty recalling information without substantial cues
Working memoryImpaired temporary storage and manipulation
Preserved recognitionRecognition memory relatively intact compared to free recall
DisinhibitionSome patients demonstrate inappropriate social behavior
IrritabilityMood lability and increased irritability
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Related Hypotheses (13)

Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Smartphone-Detected Motor Variability Correction
Score: 0.74
Aquaporin-4 Polarization Rescue
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Noradrenergic-Tau Propagation Blockade
Score: 0.71
Microglial Purinergic Reprogramming
Score: 0.70
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
Sphingolipid Metabolism Reprogramming
Score: 0.62
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38

Related Analyses (12)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (22)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40

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