| Prevalence | 30-40% clinically significant anxiety |
| Typical Onset | Often early, preceding motor symptoms |
| Any neuropsychiatric symptom | 70-90% prevalence |
| Multiple symptoms | Most patients exhibit 2-5 concurrent symptoms |
| Early onset | Symptoms often predate motor diagnosis by 2-3 years |
| Disease progression | Symptoms generally worsen over time |
| Severity | Often moderate to severe |
| Atypical features | Less guilt and self-worthlessness than primary depression |
| Course | Persistent, often worsening with disease progression |
| Orbitofrontal cortex | Reduced gray matter |
| Anterior cingulate | Metabolic dysfunction |
| Dorsolateral prefrontal cortex | Hypoactivation |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
No AI portrait yet
No comments yet. Be the first to comment!