| Binding mechanism | Flortaucipir binds to the microtubule-binding repeat domain of PHF-tau, showing selectivity for 3R and 4R tau aggregates |
| Off-target binding | Known off-target binding includes monoamine oxidase B (MAO-B) in the basal ganglia, neuromelanin in the substantia nigra, and off-target binding to amyloid plaques in some cases |
| Kinetics | Shows steady-state binding potential with reasonable test-retest reliability |
| [^18F]THK5351 | Early tau PET tracer with off-target MAO-B binding |
| [^18F]THK5317 (S-AV-45) | Enantiomer of THK5351 with improved binding characteristics |
| [^11C]PBB3 | Second-generation tracer with broader tau binding profiles |
| [^18F]MK-6240 | High affinity for PHF-tau, reduced off-target binding |
| [^18F]APN-1607 (Fluoro-PET) | Pan-tau tracer with potential for different tau morphologies |
| [^18F]PI-2620 | High binding to 3R/4R tau with favorable kinetics |
| [^18F]RO-948 | Selective for PHF-tau with minimal off-target |
| Predominant regions | Superior frontal gyrus, inferior parietal lobule, superior temporal gyrus |
| Asymmetry index | Higher contralateral-to-ipsilateral ratio compared to PSP |
| Databases | OMIMOrphanetClinicalTrialsPubMed |