| Gene Symbol | ATP7B |
| Chromosome | 13q14.3. |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | hepatocytes, where it [@czonkowska2018]
supports both copper incorporation into ceruloplasmin and biliary copper excretion |
| Subcellular Localization | and protein-protein interactions |
| Molecular Weight | 165 kDa |
| Amino Acids | 1465 aa |
| Exons | 21 |
| GeneCards | ATP7B |
| Human Protein Atlas | ATP7B |
| N-terminal metal-binding domain | Contains six tandem copper-binding repeats (CBD1-CBD6) that sequester excess copper |
| Transmembrane architecture | Eight core transmembrane domains forming the ion-transporting channel |
| P-domain | Catalytic phosphorylation site characteristic of P-type ATPases |
| A-domain | Adenosine nucleotide-binding domain essential for ATP hydrolysis |
| C-terminal tail | Contains targeting signals for subcellular localization and protein-protein interactions |
| Associated Diseases | Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia, Cirrhosis |
| Interactions | CP |
| KG Connections | 23 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |