experiment 1,119 words KG: ent-gene-9f063e98 2026-03-22
kind:experimentsection:experimentsstate:published
Contents

AAV-LRRK2 Gene Therapy IND-Enabling Study Design

🔬 Protein Info
Gene SymbolAAV
Full NameLRRK2 Gene Therapy IND-Enabling Study Design
GeneCardsAAV
Human Protein AtlasAAV
Efficacy thresholdBased on mouse studies, ≥50% LRRK2 knockdown required for phenotypic benefit
Safety margin10× the efficacious dose should show no severe adverse effects
Associated DiseasesMacaque, Rodents
Known Drugs/Compoundsnervous system, heart, gene silencing, gene editing, NDNF, Cas9
KG Connections18 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (21)

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Related Analyses (20)

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Knowledge Graph (2 edges)

ent-gene-9f063e98 data_in benchmark_ot_ad_answer_key:LRRK2
benchmark_ot_ad_answer_key:LRRK2 data_in ent-gene-9f063e98