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disease 988 words KG: ent-dise-11e44ef4
Contents

FTLD-ALS: Frontotemporal Lobar Degeneration with Motor Neuron Disease

Disease Info
Motor [Cortex](/brain-regions/cortex)TDP-43 inclusions, neuronal loss
Spinal CordAnterior horn cell loss, gliosis
Frontal/Temporal CortexTDP-43 inclusions, microvacuolation
[Hippocampus](/brain-regions/hippocampus)TDP-43 in dentate gyrus and CA1
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Related Hypotheses (4)

PARP1 Inhibition Therapy
Score: 0.74Stress Granule Phase Separation Modulators
Score: 0.72Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (2)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

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