| Motor [Cortex](/brain-regions/cortex) | TDP-43 inclusions, neuronal loss |
| Spinal Cord | Anterior horn cell loss, gliosis |
| Frontal/Temporal Cortex | TDP-43 inclusions, microvacuolation |
| [Hippocampus](/brain-regions/hippocampus) | TDP-43 in dentate gyrus and CA1 |
| Databases | OMIMOrphanetClinicalTrialsPubMed |