| Gene Symbol | GBA1 |
| Full Name | Glucocerebrosidase |
| Chromosome | 1q22 |
| Protein Type | Enzyme |
| Function | is a lysosomal enzyme encoded by the GBA1 gene that plays a critical role in the breakdown of glucocerebroside into glucose and ceramide. |
| Subcellular Localization | Lysosome |
| Molecular Weight | ~63 kDa (dimer) |
| Amino Acids | 497 aa |
| Exons | 11 |
| Pathways | Akt, Blood-Brain Barrier, Immune Response, Pi3K |
| UniProt ID | P04062 |
| NCBI Gene ID | 2629 |
| Ensembl ID | ENSG00000177693 |
| OMIM | 606463 |
| GeneCards | GBA1 |
| Human Protein Atlas | GBA1 |
| Associated Diseases | ALS, Aging, Alzheimer, Cancer, Gaucher Disease |
| Known Drugs/Compounds | BI-hTFR1, Bi-Htfr1, AAV5, AAV9, levodopa, rapamycin |
| Interactions | TFRC, LRRK2, JUN, TFR1, SNCA, MLKL |
| KG Connections | 434 knowledge graph edges |
| Databases | GeneCardsHPASTRING |