| Gene Symbol | ANO4 |
| Full Name | Anoctamin 4 |
| Aliases | Anoctamin 4 (TMEM16D |
| Chromosome | 12p11.23 |
| Protein Type | Ion Channel (CaCC), Phospholipid Scramblase |
| Function | is a member of the anoctamin family of calcium-activated chloride channels (CaCCs) and phospholipid scramblases. |
| Molecular Weight | 100 kDa |
| GeneCards | ANO4 |
| Human Protein Atlas | ANO4 |
| Calcium-activated chloride channel | ANO4 conducts chloride ions in response to intracellular calcium increases [@hartmann2020] |
| Phospholipid scramblase activity | Some anoctamin family members can flip phospholipids across the plasma membrane in a calcium-dependent manner [@piedrahita2021] |
| Voltage dependence | Shows weak voltage dependence compared to other CaCCs |
| Brain | High expression in hypothalamus, cortex, and hippocampus [@liu2019] |
| Endocrine tissues | Strong expression in pancreatic islets, adrenal gland |
| Gastrointestinal tract | Moderate expression in stomach and intestines |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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