| Gene Symbol | ARHGAP24 |
| Full Name | Rho GTPase Activating Protein 24 |
| Aliases | MPRIP |
| Chromosome | 4q21.23 |
| Function | encodes a Rho GTPase-activating protein that plays critical roles in regulating the actin cytoskeleton, cell migration, and signal transduction. |
| Subcellular Localization | specific membrane microdomains, particularly at the leading edge of migrating cells and dendritic spines |
| Amino Acids | 200 aa |
| UniProt ID | [Q8TDR0](https://www.uniprot.org/uniprot/Q8TDR0) |
| Ensembl ID | ENSG00000116675 |
| GeneCards | ARHGAP24 |
| Human Protein Atlas | ARHGAP24 |
| Stress Fiber Formation | ARHGAP24 negatively regulates RhoA signaling to control actin stress fiber formation and contractility. |
| Lamellipodia and Filopodia | Through Rac1 and Cdc42 regulation, ARHGAP24 modulates the formation of lamellipodia (broad protrusions) and filopodia (thin, finger-like projections). |
| Cell Migration | ARHGAP24 expression correlates with reduced cell migration and invasion in multiple cancer types. |
| Cytokinesis | ARHGAP24 participates in abscission during cytokinesis through RhoA regulation. |
| Associated Diseases | Alzheimer's disease pathogenesis:[@xu2018][@koh2019] |
| Databases | GeneCardsNCBI GeneHPASTRING |