| Gene Symbol | GPR137 |
| Function | encodes a 380-amino acid GPCR belonging to the Class A rhodopsin family. |
| Primary Expression | Brain) family of GPCRs, though it is now recognized as a distinct member of the rhodopsin family[@matsumoto2000] |
| Amino Acids | 380 aa |
| Ensembl ID | ENSG00000141574 |
| GeneCards | GPR137 |
| Human Protein Atlas | GPR137 |
| Transmembrane domains 1-7 | Seven alpha-helical transmembrane segments spanning the lipid bilayer |
| Extracellular N-terminus | Relatively short, involved in ligand recognition |
| Extracellular loops (ECL1-3) | Connect transmembrane helices on the extracellular side |
| Intracellular loops (ICL1-3) | Couple to G proteins and contain regulatory sites |
| C-terminal tail | Contains serine/threonine residues for phosphorylation and arrestin binding |
| TM1 | XXXN motif involved in ligand binding pocket |
| TM2 | DXDYW motif characteristic of rhodopsin family |
| TM3 | D(R/S)Y motif critical for G protein coupling |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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