| Gene Symbol | HRK |
| Full Name | Harakiri, Bcl-2 interacting protein |
| Chromosome | 12q24.12 |
| Function | encodes a pro-apoptotic member of the Bcl-2 family of proteins. |
| Primary Expression | various tissues but is particularly important in the nervous system, where it regulates developmental neuronal apoptosis and contributes to pathologic |
| Molecular Weight | 9.5 kDa |
| Amino Acids | 20 aa |
| UniProt ID | [Q9GZK8](https://www.uniprot.org/uniprot/Q9GZK8) |
| GeneCards | HRK |
| Human Protein Atlas | HRK |
| BH3-only protein | Binds to anti-apoptotic Bcl-2 family members |
| Bcl-2 neutralization | Prevents Bcl-2 from inhibiting Bax/Bak |
| Direct activation | May directly activate pro-apoptotic Bax/Bak |
| Mitochondrial pathway | Promotes cytochrome c release |
| Developmental apoptosis | Regulates naturally occurring neuronal death during development |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Cancer |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!