gene 1,061 words KG: MBD5
Contents

MBD5 Gene - Methyl-CpG Binding Domain Protein 5

🧬 Gene Info
Gene SymbolMBD5
Full NameMethyl-CpG Binding Domain Protein 5
AliasesPage for MBD5 Gene, Page for MBD5 Protein
Chromosome2q23.1.
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe brain and is essential for normal neuronal development and function
Molecular Weight225 kDa
Amino Acids80 aa
UniProt ID[Q9P523](https://www.uniprot.org/uniprot/Q9P523)
Ensembl IDENSG00000180573
GeneCardsMBD5
Human Protein AtlasMBD5
zinc Finger DomainsMBD5 contains multiple C2H2-type zinc finger domains that facilitate protein-protein interactions and DNA binding specificity.
CerebellumPurkinje cells and granule cell layer
Basal gangliaStriatum and globus pallidus
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (11)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (11)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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