gene 1,794 words KG: MS4A7 2026-03-25
kind:genesection:genesstate:published
Contents

MS4A7 Gene — Membrane-Spanning 4-Domains A7

🧬 Gene Info
Gene SymbolMS4A7
Full NameMembrane-Spanning 4-Domains A7
Chromosome11q12.2
Functionis a member of the MS4A (Membrane-Spanning 4-Domains subfamily A) gene family located on chromosome 11q12.
Primary Expressionmicroglia and other tissue-resident macrophages
Molecular Weight~21 kDa
Amino Acids187 aa
Exons5
UniProt IDQ9N1F0
NCBI Gene ID84236
Ensembl IDENSG00000166926
OMIM619604
GeneCardsMS4A7
Human Protein AtlasMS4A7
Protein Length187 amino acids
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (18)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (5)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in