gene 1,521 words KG: NOVA1 2026-03-24
kind:genesection:genesstate:published
Contents

NOVA1 — NOVA Alternative Splicing Regulator 1

🧬 Gene Info
Gene SymbolNOVA1
Full NameNOVA Alternative Splicing Regulator 1
Chromosome14q12
Functionencodes a neuron-specific RNA-binding protein on chromosome 14q12 that is a master regulator of alternative splicing in the nervous system.
Primary ExpressionNeurons (hindbrain, ventral spinal cord, hippocampus, cortex)
Amino Acids512 aa
Exons8
UniProt IDP51513
NCBI Gene ID4857
Ensembl IDENSG00000139910
OMIM602157
GeneCardsNOVA1
Human Protein AtlasNOVA1
Symbol [@darnell2010] NOVA1 [@licatalosi2008] Full NameNOVA Alternative Splicing Regulator 1 (Neuro-Oncological Ventral Antigen 1)
Associated DiseasesAlzheimer's Disease, Parkinson's Disease, Paraneoplastic Opsoclonus-Myoclonus Ataxia (POMA)
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Cryptic Exon Silencing Restoration
Score: 0.46
Cross-Seeding Prevention Strategy
Score: 0.45
Glycine-Rich Domain Competitive Inhibition
Score: 0.43
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.37
Smartphone-Detected Motor Variability Correction
Score: 0.56

Related Analyses (6)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
TARDBP Mutations in Amyotrophic Lateral Sclerosis
disease · Pages share 4 hypotheses
mitochondrial-dysfunction-neurodegeneration-comparison
disease · Pages share 4 hypotheses
Familial vs Sporadic Neurodegeneration Comparison
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses