| Gene Symbol | NTKR3 |
| Protein Type | Receptor |
| Function | NTRK3 encodes TrkC (Tropomyosin receptor kinase C), the primary receptor for neurotrophin-3 (NT-3). |
| Primary Expression | both the developing and adult nervous system, with roles in neuronal differentiation, process extension, synapse formation, and survival |
| Ensembl ID | ENSG00000140538 |
| GeneCards | NTKR3 |
| Human Protein Atlas | NTKR3 |
| PLC-γ Pathway | Phospholipase C-gamma activation leads to IP3/DAG signaling and calcium release |
| PI3K/Akt Pathway | Promotes cell survival through Akt phosphorylation |
| RAS/MAPK Pathway | Regulates gene expression, cell differentiation, and synaptic plasticity |
| Sensory Neuron Development | NT-3 is essential for the development of proprioceptive and certain sensory neurons |
| Sympathetic Neurons | Supports the development and survival of sympathetic ganglion neurons |
| Central Nervous System | NT-3 promotes differentiation of specific CNS neuronal populations |
| Muscle Innervation | NT-3 from muscle regulates the formation of neuromuscular junctions |
| Synaptic Formation | NT-3 promotes the formation of excitatory synapses |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |