| Gene Symbol | PROKR2 |
| Aliases | Page for PROKR2 Gene |
| Protein Type | Receptor |
| Function | The PROKR2 gene encodes a 384-amino acid G protein-coupled receptor |
| Primary Expression | PROKR2 is expressed in dopaminergic neurons of the substantia nigra |
| Amino Acids | 384 aa |
| UniProt ID | Q8TCW9 |
| Ensembl ID | ENSG00000101292 |
| GeneCards | PROKR2 |
| Human Protein Atlas | PROKR2 |
| Ligand binding | Binds prokineticin-1 (PK1) and prokineticin-2 (PK2) with high affinity |
| Signal transduction | Couples to Gq proteins, activating PLCbeta and leading to Ca2+ mobilization |
| Neuroprotection | PK2/PROKR2 signaling has neurotrophic effects and promotes neuron survival |
| Circadian rhythm | Involved in photic entrainment of circadian clocks |
| Olfactory function | Important for olfactory bulb development and function |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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