gene 943 words KG: TECPR2
Contents

Tectonin Beta-Propeller Repeat Containing 2

🧬 Gene Info
Gene SymbolTECPR2
Full NameTectonin Beta-Propeller Repeat Containing 2
Chromosome14q31.3
Protein TypeReceptor
FunctionIt plays critical roles in ciliary signaling, neuronal migration, and synaptic function.
Primary Expressionregions affected in Parkinson disease
UniProt IDQ9Y5P9
NCBI Gene ID1615
Ensembl IDENSG00000167962
OMIM615730
GeneCardsTECPR2
Human Protein AtlasTECPR2
AHI1Expressed in fetal and adult brain, with highest expression in cerebellum, basal ganglia, and hippocampus. Also expressed in kidney and testis. 6
GAD1Broad expression in GABAergic neurons throughout the brain, including cortex, hippocampus, basal ganglia, and cerebellum. More abundant than GAD2 in most brain regions. 7
GAD2Expressed in GABAergic neurons with synaptic localization. Higher expression in hippocampus and cerebellum compared to GAD1 in some regions. 8
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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Related Hypotheses (26)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Ganglioside Rebalancing Therapy
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.68
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
Netrin-1 Gradient Restoration
Score: 0.59
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
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Related Analyses (22)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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