gene 1,329 words KG: WDR7
Contents

WDR7 — WD Repeat Domain 7

🧬 Gene Info
Gene SymbolWDR7
Full NameWD Repeat Domain 7
Chromosome18q21.1
FunctionMitochondrial morphology control: WDR7 regulates mitochondrial dynamics by influencing fusion and fission processes.
Molecular Weight68 kDa
Amino Acids642 aa
Exons21
PathwaysTGF-β
GeneCardsWDR7
Human Protein AtlasWDR7
Highest ExpressionCerebral cortex, hippocampus, substantia nigra, cerebellum
Moderate ExpressionBasal ganglia, thalamus, hypothalamus
Expression in Spinal CordParticularly in motor neurons
CytoplasmicPredominantly cytoplasmic, associated with cytoskeletal elements
MitochondrialPartial mitochondrial localization mediating mitochondrial function
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (15)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Wilson Disease Neurodegeneration: Mechanism and Therapeutic
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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