Contents

IL-18 - Interleukin-18

🔬 Protein Info

Gene Symbol	IL
Full Name	18 - Interleukin-18
Chromosome	11q22.2.
Function	Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation.
GeneCards	IL
Human Protein Atlas	IL
Pro-inflammatory cytokines	TNF-α, IL-1β
Oxidative stress	ROS, mitochondrial dysfunction
Elevated levels	IL-18 is significantly elevated in CSF and plasma of AD patients compared to healthy controls
Disease correlation	Levels correlate with cognitive decline measured by MMSE and CDR
Pathology association	Associated with amyloid-β plaque deposition and tau hyperphosphorylation
Conversion prediction	Elevated IL-18 predicts conversion from mild cognitive impairment (MCI) to AD
Mechanistic role	Drives neuroinflammation and synaptic dysfunction
Therapeutic target	IL-18 neutralization reduces pathology in AD mouse models
Associated Diseases	CRC
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph