mechanism 1,225 words KG: ent-gene-62420ab9 2026-04-01
kind:mechanismsection:mechanismsstate:publishedDCTN1dynactinp150Perry syndromeparkinsonism
Contents

DCTN1 Dynactin Perry Syndrome Causal Chain

🔬 Protein Info
Gene SymbolDCTN1
Full NameDynactin Subunit 1 (p150^Glued)
AliasesDynactin subunit p150^Glued
Chromosome12q13.3
Protein FamilyDynactin complex
FunctionDCTN1 plays critical roles in neuronal function
Subcellular LocalizationCytoplasm, neuronal axons, growth cones
Molecular Weight150 kDa
Amino Acids238 aa
UniProt IDQ14204
NCBI Gene ID10551
OMIM604371
GeneCardsDCTN1
Human Protein AtlasDCTN1
Protein Size1,278 amino acids (~150 kDa)
Associated DiseasesALS, frontotemporal dementia
InteractionsDYNEIN, DYNACTIN, POLE, Dynein, LAMP2, MAP1LC3B
KG Connections42 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Vagal Afferent Microbial Signal Modulation
Score: 0.52
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.56
Vocal Cord Neuroplasticity Stimulation
Score: 0.50

Related Analyses (30)

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Related Experiments (6)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
tACS Connectivity Trial in Early Alzheimer's
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-62420ab9 data_in benchmark_ot_ad_answer_key:DCTN1
benchmark_ot_ad_answer_key:DCTN1 data_in ent-gene-62420ab9