| Gene Symbol | ent-gene-610500f9 |
| Risk Gene | FBXO7 — F-box Protein 7 (PARK15) |
| Variants | R378G, G886A, T474fs, L34fs, R498X, IVS6+1G>A |
| Mechanism | LOF → SCF^FBXO7 dysfunction → impaired mitophagy → mitochondrial damage accumulation → dopaminergic neuron death |
| Therapeutic Target | FBXO7 expression, mitophagy enhancement |
| Drug Candidates | AAV-FBXO7 gene therapy, mitophagy enhancers (urolithin A), PINK1-Parkin pathway activators |
| Status | Preclinical |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |