| Gene Symbol | ent-gene-83d99ff1 |
| Function | - Disrupted karyopherin trafficking |
| Inheritance | Autosomal dominant with high penetrance |
| Age of Onset | Typically 30-50 years (younger than SOD1-ALS) |
| Progression | Rapid — median survival 2-3 years from onset |
| Phenotypic Variability | Some mutations cause ALS-FTD overlap |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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