mechanism 2,751 words KG: ent-gene-83d99ff1 2026-04-01
kind:section:mechanismsevidence:strongmechanismsection:mechanismsstate:publishedtopic:causal-chaintopic:fustopic:alstopic:ftd
Contents

FUS Gene-Mechanism-Therapy Causal Chain — ALS/FTD

🔬 Protein Info
Gene SymbolFUS
Full NameFUS (Fused in Sarcoma)
Chromosome16p11.2.
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
PathwaysBlood-Brain Barrier, Hippo Pathway, Oxidative Stress, Sod1, Tdp-43
UniProt IDP35637
NCBI Gene ID2521
OMIM137035
GeneCardsFUS
Human Protein AtlasFUS
Protein Size526 amino acids (~53 kDa)
Associated DiseasesAD, ALI, ALS, AMI, Aging
Known Drugs/CompoundsAntisense Oligonucleotide, ADUCANUMAB, RNA oligonucleotides, Rna Oligonucleotides
InteractionsTARDBP, LC3, ACTB, G3BP1, BCL2, C9ORF72
SciDEX HypothesesASO-Mediated Exon Skipping to Restore FUS-TAZ Chap
KG Connections1482 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Cryptic Exon Silencing Restoration
Score: 0.46
Cross-Seeding Prevention Strategy
Score: 0.45
Glycine-Rich Domain Competitive Inhibition
Score: 0.43
VCP-Mediated Autophagy Enhancement
Score: 0.41

Related Analyses (30)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Microglial subtypes in neurodegeneration — friend vs foe
neuroscience · failed
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completed

Related Experiments (27)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-83d99ff1 data_in benchmark_ot_ad_answer_key:FUS
benchmark_ot_ad_answer_key:FUS data_in ent-gene-83d99ff1