mechanism 1,970 words KG: ent-gene-9f063e98
Contents

LRRK2 Signaling Pathway in Parkinson's Disease

🔬 Protein Info
Gene Symbolent-gene-9f063e98
LRR DomainLeucine-rich repeat region at the N-terminus, involved in protein-protein interactions
ROC DomainRas of complex (ROC) GTPase domain that binds and hydrolyzes GTP
COR DomainC-terminal of ROC, links GTPase and kinase activities
Kinase DomainSerine/Threonine protein kinase domain (the therapeutic target)
WD40 RepeatC-terminal WD40 repeat involved in substrate recognition
KG Connections22 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (58)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
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Smartphone-Detected Motor Variability Correction
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Microbial Metabolite-Mediated α-Synuclein Disaggregation
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Targeted Butyrate Supplementation for Microglial Phenotype M
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Senescent Microglia Resolution via Maresins-Senolytics Combi
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Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Retinal Vascular Microcirculation Rescue
Score: 0.72
Purinergic Signaling Polarization Control
Score: 0.71
Noradrenergic-Tau Propagation Blockade
Score: 0.71
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Orexin-Microglia Modulation Therapy
Score: 0.71
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Related Analyses (30)

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Related Experiments (30)

Proteasome-Ubiquitin System Dysfunction Validation in Parkin
clinical · proposed · Score: 0.40
Ferroptosis Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · completed · Score: 0.40
Prodromal Parkinson's Disease Biomarker Development — Early
clinical · proposed · Score: 0.40
Sirtuin Pathway Dysfunction Validation in Parkinson's Diseas
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

40690364 counteracts ent-gene-9f063e98
40690364 phosphorylates ent-gene-9f063e98
38307024 phosphorylates and inactivates ent-gene-9f063e98
33177079 is recruited to ent-gene-9f063e98
33177079 recruits ent-gene-9f063e98
33177079 recruits JIP4 to lysosomes via phosphorylation of ent-gene-9f063e98
33177079 is orchestrated by ent-gene-9f063e98
32853409 phosphorylates ent-gene-9f063e98
34125248 is an endogenous substrate of ent-gene-9f063e98
38307024 phosphorylates ent-gene-9f063e98

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