mechanism 2,012 words KG: ent-gene-0c093647 2026-04-01
PSEN2presenilinAlzheimer's diseasecausal chainamyloidgamma secretaselate-onset ADfamilial AD
Contents

PSEN2 Presenilin 2 AD Causal Chain

🔬 Protein Info
Gene Symbolent-gene-0c093647
Chromosome1q42.13
FunctionAspartyl protease, gamma-secretase catalytic subunit
ProteinPresenilin 2 (448 amino acids)
InheritanceAutosomal dominant
Age of OnsetTypically 55-75 years (mean ~65)
KG Connections4 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.56
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.41
APOE-Dependent Autophagy Restoration
Score: 0.61
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.40
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.40

Related Analyses (30)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (4)

Metal Ion Homeostasis Dysregulation in Alzheimer's Disease
validation · proposed · Score: 0.40
Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40
Creation and validation of 3xAD-ChAT-Cre mouse model
validation · proposed · Score: 0.90
Adoptive transfer of TCRAβ-Tregs in AD mouse model
validation · proposed · Score: 0.90

Knowledge Graph (4 edges)

ent-gene-0c093647 data_in ad_genetic_risk_loci:PSEN2
ent-gene-0c093647 data_in benchmark_ot_ad_answer_key:PSEN2
ad_genetic_risk_loci:PSEN2 data_in ent-gene-0c093647
benchmark_ot_ad_answer_key:PSEN2 data_in ent-gene-0c093647