protein 1,532 words KG: 1433PROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

14-3-3 Proteins — Adapter and Scaffold Proteins

🔬 Protein Info
Gene Symbol1433PROTEIN
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionmotor neurons and may contribute to selective vulnerability - TDP-43 pathology: 14-3-3 proteins interact with TDP-43 and may influence its aggrega
Subcellular Localization5. **Transcriptional regulation**: Interact with transcription factors
Molecular Weight28 kDa
Amphipathic groovebinds phosphorylated serine/threonine motifs
N-terminal dimerization domainforms functional dimers
C-terminal regulatory tailmodulates interactions
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

Synthetic Biology Approach: Designer Mitochondrial Export Sy
Score: 0.36
Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Synthetic Lethality and PARP Inhibition in Neurodegener
mechanism · Pages share 4 hypotheses
Quantum Biology and Coherent Energy Transfer in Neurode
mechanism · Pages share 4 hypotheses
Mitochondrial Fusion in Neurodegeneration
mechanism · Pages share 4 hypotheses
Diffusion MRI (DTI) in Neurodegeneration
mechanism · Pages share 4 hypotheses