| Gene Symbol | AMPARECEPTOR |
| Aliases | AMPARECEPTORPROTEIN |
| Function | AMPA receptors are essential for synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), the cellular correlates of learning and memory. |
| GeneCards | AMPARECEPTOR |
| Human Protein Atlas | AMPARECEPTOR |
| GluA1 (GRIA1) | Essential for long-term potentiation (LTP) induction. The C-terminal tail interacts with PDZ domains of synapse-associated proteins[@s2024]. |
| GluA2 (GRIA2) | Controls Ca²⁺ permeability through RNA editing at the Q/R site. Edited GluA2 subunits render receptors impermeable to Ca²⁺[@d2023]. |
| GluA3 (GRIA3) | Participates in regulatory functions and behavioral plasticity[@a2022]. |
| GluA4 (GRIA4) | Critical for neural development and plasticity during critical periods[@m2024]. |
| GRIP1/2 (GRIP1) | Scaffolding proteins that anchor AMPA receptors to the postsynaptic density[@y2023]. |
| PICK1 | Regulates endocytosis and recycling of AMPA receptors[@j2022]. |
| NSF (NSF) | Facilitates receptor recycling and prevents degradation[@k2023]. |
| stargazin | Transynaptic protein that controls synaptic targeting and gating[@s2024a]. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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