| Gene Symbol | AMPARECEPTORSUBUNITS |
| Aliases | AMPARECEPTORSUBUNITS |
| Extracellular N-terminal domain | Responsible for subunit assembly and receptor tetramerization |
| Ligand-binding domain (LBD) | Binds glutamate and allosteric modulators; contains the flip and flop splice variants that determine desensitization kinetics |
| Transmembrane domain | Four hydrophobic segments (M1-M4) that form the ion channel pore |
| C-terminal intracellular domain | Regulates trafficking, phosphorylation, and interaction with scaffolding proteins like PSD-95 |
| Long-term depression (LTD) | Activity-dependent weakening of synapses, requiring GluR2 endocytosis |
| Homeostatic plasticity | Scaling of synaptic strength in response to activity changes |
| GluR2-containing receptors | Predominantly Na⁺ permeable, poorly permeable to Ca²⁺ due to Q/R site editing |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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