| Gene Symbol | ANKYRINREPEATDOMAIN11PROTEIN |
| Aliases | ANKYRINREPEATDOMAIN11PROTEIN |
| Chromosome | 16q24.3 |
| Ankyrin repeat domain | The central region contains 15 ankyrin repeats, protein-protein interaction motifs that mediate binding to various transcription factors and chromatin regulators. [@ankyrin2017] |
| C-terminal repression domain | This region contains additional regulatory functions and nuclear localization signals. [@ankrdc] |
| p53 regulation | ANKRD11 enhances p53 transcriptional activity, promoting cell cycle arrest and apoptosis in response to genotoxic stress. [@ankrdj] |
| Chromatin relaxation | The protein facilitates DNA repair by promoting chromatin accessibility at damage sites. [@ankrd2019] |
| Genome stability | ANKRD11 deficiency leads to increased genomic instability and sensitivity to DNA-damaging agents. [@ankrdk] |
| [Tau](/proteins/tau) pathology | The protein influences tau phosphorylation and aggregation through regulation of tau-modifying kinases and phosphatases. [@ankrdm] |
| Neuronal survival | ANKRD11's anti-apoptotic function through p53 regulation may protect neurons from Aβ-induced cell death. [@ankrd2020] |
| Synaptic function | Transcriptional dysregulation caused by ANKRD11 alterations may impair synaptic plasticity genes critical for memory formation. [@ankrd2020a] |
| Mitochondrial function | The protein regulates transcription of mitochondrial biogenesis genes, relevant to PD's mitochondrial dysfunction. [@ankrdo] |
| Dopaminergic neuron survival | ANKRD11's neuroprotective functions may be particularly important for vulnerable dopaminergic neurons. [@ankrdp] |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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