protein 930 words KG: CACNA1SPROTEIN
Contents

CACNA1S Protein - Cav1.1 Calcium Channel

🔬 Protein Info
Gene SymbolCACNA1S
Full NameCalcium Voltage-Gated Channel Alpha Subunit 1S
AliasesPage for CACNA1S Gene, Page for CACNA1S Protein
Chromosome1q31.3
Protein TypeChannel
FunctionCACNA1S/CaV1.1 has several critical functions:
Primary Expressionskeletal muscle
Molecular Weight~212 kDa
Amino Acids873 aa
Exons44 exons spanning ~80 kb
GeneCardsCACNA1S
Human Protein AtlasCACNA1S
Gene LocationChromosome 1q31.3
Protein Length1,873 amino acids
IsoformsMultiple splice variants with tissue-specific expression
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (8)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (11)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (5)

s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice
falsification · proposed · Score: 0.40
s:** - Compare uptake with/without magnetic particles using
falsification · proposed · Score: 0.40
Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.40
Blood-Brain Barrier Aging and Neurodegeneration — From Leaka
validation · proposed · Score: 0.40
Vascular Contribution to Alzheimer's Disease — Beyond Amyloi
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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