| Gene Symbol | CAMK2B |
| Aliases | CAMK2BPROTEIN |
| Chromosome | 22q12.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 60 kDa |
| Amino Acids | 542 aa |
| Exons | 20 |
| GeneCards | CAMK2B |
| Human Protein Atlas | CAMK2B |
| Actin Binding | Beta subunit contains an actin-binding domain that targets CaMKII to dendritic spines |
| Synaptic Localization | Essential for proper CaMKII localization to postsynaptic densities |
| Spine Morphology | Regulates dendritic spine formation and maintenance |
| Synaptic Plasticity | Both beta and alpha subunits contribute to LTP and LTD |
| Calcium/Calmodulin Activation | Autophosphorylation at T286 (alpha) and T287 (beta) creates calcium-independent activity |
| Substrate Specificity | Different substrate preferences between alpha and beta subunits |
| Associated Diseases | neurodegeneration |
| Interactions | PLCB3 |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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