PLCB3

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLCB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

PLCB3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with spondylometaphyseal dysplasia with corneal dystrophy. Connected to 14 entities in the SciDEX knowledge graph.

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graph TD
    PLCB3["<b>PLCB3</b>"]
    IL_8["IL-8"]
    PLCB3 -->|"regulates"| IL_8
    Toll_like_receptor_signaling(["Toll-like receptor signaling"])
    PLCB3 -->|"regulates"| Toll_like_receptor_signaling
    spondylometaphyseal_dysplasia_with_corne{"spondylometaphyseal dysplasia with corneal dystrop"}
    PLCB3 -->|"causes"| spondylometaphyseal_dysplasia_with_corne
    phosphoinositide_signaling(["phosphoinositide signaling"])
    PLCB3 -->|"participates in"| phosphoinositide_signaling
    lipid_metabolism["lipid metabolism"]
    PLCB3 -->|"associated with"| lipid_metabolism
    NOD_like_receptor_signaling(["NOD-like receptor signaling"])
    PLCB3 -->|"associated with"| NOD_like_receptor_signaling
    NF__B_signaling(["NF-kappaB signaling"])
    PLCB3 -->|"associated with"| NF__B_signaling
    protein_kinase_C_["protein kinase Calpha"]
    PLCB3 -->|"activates"| protein_kinase_C_
    NF__B_p65["NF-kappaB p65"]
    PLCB3 -->|"activates"| NF__B_p65
    SMYD3["SMYD3"]
    PLCB3 -->|"interacts with"| SMYD3
    CAMK2B["CAMK2B"]
    PLCB3 -->|"interacts with"| CAMK2B
    style PLCB3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0