protein 1,602 words KG: CATHEPSINAPROTEIN 2026-03-27
kind:proteinsection:proteinsstate:published
Contents

Cathepsin A Protein (CTSA)

🔬 Protein Info
Gene SymbolCTSA
Full NameCathepsin A (Lysosomal Protective Protein)
Chromosome20q13.12
Protein TypeEnzyme
FunctionCTSA encodes cathepsin A (also called protective protein/cathepsin A, PPCA), a multifunctional lysosomal enzyme with several important functions:
Primary Expressionregions associated with learning and memory, including the hippocampus and cerebral cortex[@demaret2004]
Subcellular Localization</strong></td><td>Lysosome, Secreted</td></tr>
Molecular Weight46 kDa
Amino Acids419 aa
Exons15
UniProt IDP10619
NCBI Gene ID2151
Ensembl IDENSG00000166664
OMIM613512
GeneCardsCTSA
Human Protein AtlasCTSA
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (14)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
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What are the mechanisms by which gut microbiome dysbiosis in
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Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
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clinical · Pages share 5 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 5 hypotheses
A Placebo-Controlled, Double-Blind, Parallel-Group, 18-
clinical · Pages share 5 hypotheses