| Gene Symbol | CAV12PROTEIN |
| Function | Cav1.2 channels are among the most extensively studied ion channels in the context of Alzheimer's disease (AD) and Parkinson's disease (PD) due to their central role in calcium dysregulation—a hallmar |
| Subcellular Localization | the cell membrane. It belongs to the Cav1 (L-type) channel family and is composed of a pore-forming α1C subunit (CACNA1C |
| Molecular Weight | ~250 kDa for α1 subunit |
| GeneCards | CAV12PROTEIN |
| Human Protein Atlas | CAV12PROTEIN |
| L-type Calcium Channel | L-type Calcium Channel Protein |
| Transmembrane segments | 24 segments (6 per domain) |
| Selectivity filter | EEEE motif (positions 1394-1397) |
| Voltage sensor | Positively charged S4 segments |
| C-terminal tail | Multiple regulatory domains (CaM, CaMKII) |
| Molecular weight | ~250 kDa for α1 subunit |
| Approach | Status |
| Nifedipine | Dihydropyridine |
| Isradipine | Research |
| Associated Diseases | neurodegeneration |
| Interactions | NMDA |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |